I think "I would take a pill that made me more rational." is poorly worded. Am I taking a pill that makes me more rational when I take my antidepressant? I would say that, technically, yes, indirectly, it is a pill that makes me more rational, but I'm sure that isn't quite what you meant.
i first answered no, then it occurred to me that i have taken antidepressants so i switched my answer to yes